Date of Report (Date of earliest event reported): May 8, 2020
(Exact name of registrant as specified in its charter)
(State or other jurisdiction
of incorporation)
File Number)
(IRS Employer
Identification Number)
33 Hayden Avenue
Lexington, Massachusetts
(Address of registrant’s principal executive office)
 (Zip code)
(617) 621-8097
(Registrant’s telephone number, including area code)

(Former name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
 Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
 Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
 Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
 Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading symbol(s)Name of each exchange on which registered
Common Stock, par value $0.0001 per shareDRNAThe Nasdaq Global Select Market
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 or Rule 12b-2 of the Securities Exchange Act of 1934.
Emerging growth company  

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☐

Item 7.01 Regulation FD Disclosure.
The Company from time to time presents and/or distributes to the investment community at various industry and other conferences slide presentations to provide updates and summaries of its business. The Company is posting to the “Investors” portion of its website at http://investors.dicerna.com/ a copy of its current corporate slide presentation. These slides are attached to this Current Report on Form 8-K as Exhibit 99.1. The Company undertakes no obligation to update, supplement or amend the materials attached hereto as Exhibit 99.1.
The information in Item 7.01 of this Form 8-K, including Exhibit 99.1 attached hereto, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

By:/s/ Douglas M. Fambrough, III
Douglas M. Fambrough, III, Ph.D.
Chief Executive Officer

Corporate Overview May 2020 © 2020 DICERNA

Forward-looking Statements This presentation has been prepared by Dicerna Pharmaceuticals, Inc. (“we,” “us,” “our,” “Dicerna,” or the “Company”) and includes forward-looking statements. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements. Examples of forward-looking statements include, among others, statements we make regarding: (i) the therapeutic and commercial potential of nedosiran (DCR-PHXC), RG6346 (DCR-HBVS), DCR-A1AT and the GalXC™ platform; (ii) expectations that our current cash and future collaborative revenue will fund operations into 2023; (iii) research and development plans and timelines, as well as regulatory pathways and plans, related to nedosiran, RG6346, DCR-A1AT and GalXC; (iv) the potential of Dicerna’s technology and drug candidates in the Company’s research and development pipeline; (v) the Company’s collaborations with Novo Nordisk A/S; Roche; Eli Lilly and Company; Alexion Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH; and Alnylam Pharmaceuticals, Inc.; and (vi) the Company’s strategy, business plans and focus. The process by which an early-stage investigational therapy such as nedosiran and an early-stage platform such as GalXC could potentially lead to an approved product is long and subject to significant risks. Applicable risks and uncertainties include, but are not limited to those risks identified under the heading "Risk Factors" included in the Company’s most recent Form 10-K filing and in other subsequent filings with the Securities and Exchange Commission. These risks and uncertainties include, among others, the impact to, and potential for delays in, the current and future conduct of the business of the Company, its clinical programs and operations as a result of the COVID-19 pandemic; the cost, timing and results of preclinical studies and clinical trials and other development activities; the likelihood of Dicerna’s clinical programs being executed within timelines provided and reliance on the Company’s contract research organizations and predictability of timely enrollment of subjects and patients to advance Dicerna’s clinical trials; the potential for future data to alter initial and preliminary results of early-stage clinical trials; the unpredictability of the duration and results of the regulatory review of Investigational New Drug (IND) applications and Clinical Trial Applications that are necessary to continue to advance and progress the Company’s clinical programs and the regulatory review of submissions relevant to regulatory agencies for marketing approvals, including New Drug Applications (NDAs); market acceptance for approved products and innovative therapeutic treatments; competition; the possible impairment of, inability to obtain and costs of obtaining needed intellectual property rights; possible safety or efficacy concerns that could emerge as new data are generated in R&D; that the Company may not realize the intended benefits of its collaborations; general business, financial and accounting risks; and the risks and potential outcomes from litigation. Dicerna is providing this information as of this date and does not undertake any obligation to update or revise it, whether as a result of new information, future events or circumstances or otherwise. Additional information concerning Dicerna and its business may be available in press releases or other public announcements and public filings made after the date of this information. Dicerna™, GalXC™ and PHYOX™ are trademarks of Dicerna Pharmaceuticals, Inc. 2 ©2020 DICERNA

Dicerna Vision and Strategy VISION STRATEGY Develop and commercialize our core Maximize the impact high-probability-of-success programs either alone or in collaboration of RNAi on medicine with partners Broadly enable the use of our GalXC™ technology by collaborating with therapeutic area leaders on non-core opportunities 3 ©2020 DICERNA

Dicerna Pipeline of Core and Collaborative Programs TARGET DISCOVERY/ CLINICAL PROOF-OF- REGISTRATION DICERNA’S CANDIDATE PRECLINICAL INDICATION RESEARCH CONCEPT TRIALS TRIALS PRODUCT RIGHTS Nedosiran Primary 100% (DCR-PHXC) Hyperoxaluria RG6346* Hepatitis B Virus U.S. opt-in Core (DCR-HBVS) Programs DCR-A1AT 100% U.S. A1AT Liver Disease ALN-AAT02 Alnylam ex-U.S. opt-in DCR-undisclosed Undisclosed 100% *Under its agreement with Roche, Dicerna has the option to co-fund pivotal development for heightened royalties and co-promotion rights in U.S. ORPHAN PREVALENT NASH Complement-mediated Cardiometabolic HBV infection Liver-related cardiometabolic 1 target 4 targets (CM; liver and non-liver), RG6346 and multiple potential diseases neurodegeneration and pain Discovery/Research Initially two targets; ALXN targets 30+ potential targets Up to 8 CM targets exercised option for two more DRNA option to co-fund dev. 2 Novo programs: DRNA opt-in targets in Dec. 2019 DRNA retains rights to certain and co-promote in U.S. DRNA retains rights to neuro orphan indications • First target selected under 2 new orphan programs • First IND/CTA expected late research and development (Novo retains opt-in rights) 2020 (LY3561774) collaboration Initial targets selected • March 2020: LY3819469 (DCR-CM2) advances to LLY preclinical pipeline Currently active discovery or preclinical-stage liver program 4 Currently active discovery or preclinical-stage non-liver program ©2020 DICERNA

The Foundation of Our Value Delivery agents GalXC RNAi trigger • Proprietary, patented RNA interference (RNAi) technology with potential to extend to diverse tissues beyond the liver • Clinically compelling pharmaceutical properties Subcutaneously delivered → convenient administration Long duration of action → infrequent dosing High target specificity → predictable activity High therapeutic index → broad applicability Established manufacturing → scalable 5 ©2020 DICERNA

Multiple Upcoming Milestones*  Nedosiran: First multidose results from PHYOX3 open-label clinical trial  Nedosiran: PHYOX2 pivotal clinical trial enrollment completion – timing TBD  RG6346: Phase 1 proof-of-concept data from all existing cohorts – August 2020 R&D Day  GalXC: Present data for extending GalXC technology to additional tissues – August 2020 R&D Day  Nedosiran: Present updated multidose data from PHYOX3 open-label clinical trial – August 2020 R&D Day  Collaborative Program: IND or CTA filing for LY3561774 – late 2020  DCR-A1AT or ALN-AAT02: First patient dosing in Phase 1/2 trial – timing TBD  Nedosiran: PHYOX2 last patient out – timing TBD * Based on changes at trial sites related to COVID-19, on March 26, 2020, Dicerna withdrew its previous expectation for enrollment completion timing. Dicerna will provide a revised timing estimate for PHYOX2 enrollment completion at a later date, and evaluate its potential effect on timing of subsequent activities, such as the nedosiran NDA submission. Dicerna is continuing to evaluate the impact to future studies of nedosiran and future activities in its other clinical trials and development programs and plans to provide an update at a future date. 6 ©2020 DICERNA

Primary Hyperoxaluria 7 ©2020 DICERNA

Primary Hyperoxaluria (PH) A family of ultra-rare, life-threatening genetic disorders resulting in renal complications • Three known types of PH, each resulting from a mutation in one Known Types of Primary Hyperoxaluria of three different genes, cause enzyme deficiencies manifesting PH1 PH2 PH3 Genetic mutation Genetic mutation Genetic mutation in overproduction of oxalate AGXT GRHPR HOGA1 • Abnormal production and GO accumulation of oxalate leads to: - Recurrent kidney stones LDHA Nedosiran - Nephrocalcinosis (deposition of calcium in the kidney) Oxalate - Chronic kidney disease that may progress to end-stage renal Calcium disease, requiring regular dialysis oxalate and transplant (dual liver-kidney crystallization or kidney) - Systemic oxalosis, which also impacts the heart, skin, eyes, bones Impacted by Kidney Kidney systemic stones function • Dicerna’s nedosiran silences LDHA, oxalosis preservation the ultimate step in the oxalate production pathway GO = glycolate oxidase LDHA = lactate dehydrogenase A 8 ©2020 DICERNA

PHYOX1: Phase 1 Single-Dose Study of Nedosiran in PH1 and PH2 Participants 14/18 participants achieved normalization or near-normalization PHYOX1: Mean Urinary Oxalate Levels by Dose* 3.0 PHYOX1 open-label study included: 3.0 mg/kg • ) 6.0 mg/kg • 18 participants dosed: PH1 hr 2.5 (n=15) and PH2 (n=3) 2.0 ̶ Genetically confirmed diagnosis SEM ± ̶ Uox ≥0.7 mmol/24hr 1.5 2 ̶ eGFR ≥30 mL/min/1.73m Mean 1.0 • 1.5, 3.0, 6.0 mg/kg doses ≥0.46 & <0.60 near-normal delivered subcutaneously Content Uox (mmol/24 0.5 <0.46 normal • Normalization or near-normalization 0.0 in 60%, 83% and 100% of PH1 0 8 15 29 43 57 71 85 99 155 183 197 239 253 281 379 Nedosiran Days After Single Dose patients at doses of 1.5, 3.0 and 6.0 Day One mg/kg, respectively Pts. Reaching Normalization Max Reduction Uox (%) • 2 of 3 PH2 patients with PH Type Dose (mg/kg) or Near-Normalization (%) Mean (range) normalization or near-normalization 1.5 (n=5) 3 (60) 51 (28-72) • The only drug-related AEs were mild PH1 3.0 (n=6) 5 (83) 72 (62-80) to moderate injection-site reactions 6.0 (n=4) 4 (100) 72 (35-100) 1.5 (n=1) 0 (0) 39 • No drug-related SAEs were observed PH2 3.0 (n=2) 2 (100) 54 (42-66) *Days with at least two values ClinicalTrials.gov: NCT03392896 9 ©2020 DICERNA

PHYOX3: Open-Label Multidose Study of Nedosiran Analysis of preliminary interim data in March 2020 • PHYOX3 long-term, multidose, open-label rollover extension trial ongoing - 14* participants enrolled as of preliminary analysis - 4 participants had received at least three monthly doses of nedosiran • Nedosiran appeared generally well tolerated, with AE profile comparable to that observed in the PHYOX1 Phase 1 clinical trial - No injection-site reactions - No drug-related severe AEs - 2 serious AEs determined by investigator to be unrelated to the study drug • Normalization or near-normalization of urinary oxalate levels achieved on at least two visits for all 4 patients receiving at least three monthly doses - Normal and near-normal urinary oxalate levels defined as <0.46 mmol and ≥0.46 to <0.6 mmol, respectively, during a 24-hour period • Multidose data expected to be presented at August 2020 R&D Day *As of May 4, 2020, 17 patients had enrolled in the study. 10 ©2020 DICERNA

Nedosiran Clinical Trial Program to NDA Filing Coordinated program of clinical trials to support a broad label in PH Pivotal Study Package Trial Description/Details Status PH Type Study 201: Pivotal, double-blind, randomized, placebo-controlled Enrolling trial (2:1 randomization) 1,2 n=~36 Monthly fixed-dose, enabling prefilled syringes at launch Study 301: Long-term, multi-dose, open-label extension; rollover Enrolling 1,2,3 study open to all patients in PHYOX trials Additional Supportive Studies Study 104: Double-blind, randomized, placebo-controlled study in Enrollment TBD† 3 patients with primary hyperoxaluria type 3 (PH3) Study 204: Multi-dose trial in patients (birth to adult) with PH and Enrollment TBD† 1,2 end-stage renal disease (ESRD) Study 203: Open-label study in children 2-5 yrs Enrollment TBD† 1,2 Due to impacts from the COVID-19 pandemic announced on March 26, 2020, Dicerna is evaluating the timing for PHYOX2 enrollment completion and the impact to future studies of nedosiran and plans to provide an update at a future date. †Initiation also subject to regulatory approvals. 11 ©2020 DICERNA

Nedosiran: The Only RNAi Drug Candidate in Development for All PH Types High unmet medical need across all PH types can be addressed Genetics of PH All Known PH1 PH2 PH3 Physician PH Types Patient & Education Caregiver Genetic prevalence 8.23 5.08 12.58 25.89 Support (per million) U.S. 2,681 1,655 4,098 8,434 Availability of Nedosiran EU 2,607 1,609 3,986 8,202 Estimated Prevalent 5,288 3,264 8,084 16,636 Population (U.S. + EU) • Dicerna estimates nedosiran peak sales between $500M and $1B Pre- and post-launch activities will improve • Dicerna to seek collaborative partner for commercialization ex-U.S. diagnosis across all PH types J Am Soc Nephrol. 2015 Oct;26(10):supp, and applied to population sizes 12 ©2020 DICERNA

Chronic Hepatitis B Virus Infection 13 ©2020 DICERNA

Hepatitis B: A Severe, Global Unmet Medical Need • Significant worldwide prevalence: ~292 million infected • Causes more than 887,000 deaths per year • Current treatments are rarely effective in achieving functional cures • Dicerna is collaborating with Roche to develop RG6346 (DCR-HBVS) and potentially other agents for the treatment of HBV the treatment Electron micrograph of HBV showing infectious viral particles (~42 nm) and non-infectious sub-viral “decoy” particles (~22 nm) and filaments Sources: Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. The Lancet Gastroenterology and Hepatology. Volume 3, Issue 6, June 2018, Pages 383-403. World Health Organization. Finding a cure for hepatitis B: are we close? https://www.who.int/hepatitis/news-events/hbv-cure-overview/en/. Accessed Dec. 30, 2019. 14 ©2020 DICERNA

GalXC RNAi May Play a Key Role in Establishing a Functional HBV Cure Organization of the HBV genome enables effective RNAi targeting of multiple viral functions The Promise of RNAi for HBV Overlapping mRNAs and protein-coding regions enable targeting multiple HBV genes and proteins with a single GalXC trigger • RNAi can simultaneously inhibit RG6346 multiple viral activities due to target site overlapping transcripts • RNAi can target all viral transcripts S gene (HBsAg): from cccDNA and integrated genomes P gene: Surface protein. Hepatocyte entry; Polymerase. Immune decoy Current HBV Therapies Are Inadequate Viral genome production • Functional cure of chronic HBV would be the best treatment outcome - Defined by the lack of detectable C gene: HBsAg in serum (often associated Core protein. with seroconversion to anti-HBsAg+) Capsid assembly; E antigen secretion X gene: • Interferons and NUCs are the only Epigenetic approved therapies, but offer very maintenance low functional cure rates of viral genome 15 ©2020 DICERNA

Single-Dose GalXC-HBVS Reduced HBsAg to Below Lower Level of Detection Striking pharmacodynamic differences between targeting in the S alone vs. S and X ORFs in preclinical model HDI-HBV HDI-HBV Plasmid Model Vehicle control • Immunohistochemical (cccDNA-dependent) staining of mouse liver sections for HBV Core 100 Protein reveals differential Vehicle control subcellular localization in 10 S and X the HDI-HBV plasmid model SEM - genes targeted 1 X targeted • Silencing of X gene leads to 0.1 nuclear localized Core Only S %HBsAg +/ %HBsAg GalXC-HBVS Protein likely driving (Normalized to d0) gene targeted 0.01 additional S expression 2/3 BLOQ 3/3 BLOQ 0.001 • These results have been -1 0 1 2 3 4 5 6 7 8 9 10 11 12 reproduced using alternative GalXC-HBVS 3mg/kg qWx3 Time (weeks) guide strand sequences (i.e., different mRNA binding sites) for both GalXC-HBVS • GalXC-HBVS: ≥3.9 log reduction, long duration of activity and GalXC-HBVX • X gene targeted: 3.0 log reduction, shorter duration of activity 16 ©2020 DICERNA

RG6346 (DCR-HBVS) Clinical Program for Proof of Concept Includes placebo-controlled studies in both NUC-naïve and NUC-experienced patients Three-Part Study in Healthy Volunteers and Patients With Chronic HBV Infection Placebo-controlled, single-ascending-dose study Completed RG6346 dose cohorts: Group A in healthy volunteers n=30 0.1, 1.5, 3.0, 6.0, 12.0 mg/kg Placebo-controlled, single-dose study in patients RG6346 dose cohort: with no prior use of nucleoside or nucleotide Dosing 3.0 mg/kg Group B analogue (NUC) therapy (NUC-naïve) with chronic n=8 (NUCs initiated after 12 wks) HBV infection Dosing Placebo-controlled, multiple-ascending-dose RG6346 dose cohorts: n=18 study in NUC-experienced patients with chronic 1.5, 3.0, 6.0 mg/kg; Group C Enrolling HBV infection 4 monthly doses 6.0 mg/kg cohort • Patients with ≥1 log HBsAg suppression will continue in observational follow-up after 12 weeks in Group B, 16 weeks in Group C. Groups B and C are now represented in extended follow-up phase. • Data expected to be presented at R&D Day event in August 2020 17 ©2020 DICERNA

Alpha-1 Antitrypsin Deficiency- Associated Liver Disease 18 ©2020 DICERNA

Alpha-1 Antitrypsin Deficiency-Associated Liver Disease Most disease is caused by a single missense allele that forms aggregates in hepatocytes • Alpha-1 antitrypsin (A1AT): predominantly α1-Antitrypsin Deficiency produced in liver and secreted into blood Z mutation Glu342→Lys342 • Pi*ZZ genotype of the SERPINA1 gene affects Polymerization of α1-antitrypsin 95% of patients with A1AT deficiency • The Z-allele of the SERPINA1 gene produces an abnormal form of the protein, which can form pathological aggregates in hepatocytes Intracellular accumulation Plasma deficiency - Abnormal A1AT protein aggregates neonatal hepatitis, liver cirrhosis early-onset emphysema accumulate in liver, triggering injury cascade that can lead to liver disease - Lack of normal A1AT protein can lead to lung disease, especially in smokers Toxic gain of function Loss of function deficiency Janciauskiene et al. 2013: Acute Phase Proteins 19 ©2020 DICERNA

Activity of DCR-A1AT in Mice and Non-Human Primates Potency and duration of action Z-AAT Protein Knockdown in PiZ Mice A1AT Protein Knockdown in Monkeys PBS 3.0 mg/kg 3.0 mg/kg 10.0 mg/kg 10.0 mg/kg SEM SEM ± ± Mean Mean Mean Mean AAT Protein Protein Concentration AAT - Relative A1AT Protein Concentration Protein A1AT Relative Relative Z Relative Single Weeks Post-Dose Single Weeks Post-Dose Subcutaneous Dose Subcutaneous Dose • Sustained, dose-dependent knockdown of A1AT protein in both mice and monkeys 20 ©2020 DICERNA

DCR-A1AT Clinical Program for Proof of Concept Part of larger A1AT clinical plan to achieve a rapid path to approval • Two-part study: Single-ascending-dose (SAD) in healthy volunteers (HVs) and multiple-ascending-dose (MAD) in patients with A1AT deficiency-associated liver disease - HVs: SAD study, placebo-controlled, up to 36 participants – ongoing • 5 dose cohorts: 0.1, 1.0, 3.0, 6.0, 12.0 mg/kg, with a potential additional cohort • Overlapping cohorts • PK/PD data will be used to determine MAD regimen - Patients with A1AT deficiency-associated liver disease: MAD study, up to 24 patients – not yet initiated • 2-3 dose cohorts: dose levels dependent on PK/PD data from HVs • 2-4 doses to be administered within a 13-week period • We believe the Phase 1/2 program can enable a pivotal trial without additional studies 21 ©2020 DICERNA

Dicerna-Alnylam Collaboration on A1AT Deficiency-Associated Liver Disease Agreement struck to advance candidate(s) with greatest potential to benefit patients • Development and commercialization agreement for A1AT deficiency-associated liver disease in April 2020 − Dicerna takes development responsibility for DCR-A1AT and Alnylam’s ALN-AAT02 − Dicerna to initiate studies designed to select best candidate for continued clinical development − Dicerna to advance best candidate through development and regulatory review − Alnylam has opt-in right post Phase 3 to commercialize selected product candidate ex-U.S. • If Alnylam opts in: − No upfront payment; each party to pay tiered royalties to the other based on net product sales generated in its territory − Rates dependent on which candidate is commercialized • Range payable to Dicerna: low-double-digit  high-teens royalties • Range payable to Alnylam: low-single-digit  high-single-digit royalties • If Alnylam does not opt in: − Dicerna retains worldwide rights − Dicerna would pay Alnylam milestones on approval and commercial sales − Royalties to Alnylam on net product sales, depending on selected candidate, from low single-digits  low double-digits 22 ©2020 DICERNA

Corporate Collaborations 23 ©2020 DICERNA

Enhancing Value Through GalXC Collaboration Strategy Successive collaborations increasing in scope and value $175M upfront $75M total annuals $200M upfront $50M equity • RG6346 (DCR- • 30+ potential HBVS) and multiple targets for liver- potential HBV- related CM diseases $100M upfront related targets $100M equity • 2 Novo programs: DRNA option to co- • DRNA opt-in • Up to 8 fund development cardiometabolic and co-promote in • DRNA retains rights to 2 new orphan $22M upfront (CM) targets, liver U.S. programs (Novo $15M equity and non-liver retains opt-in rights) • 4 complement- • Neurodegeneration, Scope, Responsibility, Value Scope, Responsibility, $10M upfront mediated targets pain targets • 1 NASH target Dicerna retains opt-in rights • $20M option • DRNA retains rights • $5M option exercised to certain neuro exercised orphan indications 2017 2018 2019 24 ©2020 DICERNA

Summary 25 ©2020 DICERNA

Elements of Portfolio Strategy We seek to generate value across the full spectrum of GalXC clinical applications Core Programs Collaborative Programs Highest Lower Resource Resource Investment Investment Cardiometabolic and Liver-related Diseases • Primary hyperoxaluria Chronic HBV • HBV (U.S. opt-in) Infection Cardiometabolic, • Alpha-1 antitrypsin deficiency- Neurodegeneration, Pain associated liver disease Complement-mediated Diseases • Undisclosed liver program NASH • Novo Nordisk program (U.S. opt-ins) A1AT Deficiency- • Future programs beyond the liver associated Liver Disease Value Value-Add Retention 26 ©2020 DICERNA

Strong Cash Position Provides Runway Through Commercialization Additional cash upside expected from collaboration milestones and potential royalties on product sales • Company well capitalized with approximately $706.9 million in unaudited cash, cash equivalents and marketable securities as of March 31, 2020 • We expect our current cash and estimated future proceeds from existing collaborations will fund operations into 2023* *Expectations provided by Dicerna in its press release dated May 7, 2020 and are current as of this date. Dicerna disclaims any obligation to update or reaffirm expectations and only provides guidance in a Regulation FD compliant manner. 27 ©2020 DICERNA

Multiple Upcoming Milestones*  Nedosiran: First multidose results from PHYOX3 open-label clinical trial  Nedosiran: PHYOX2 pivotal clinical trial enrollment completion – timing TBD  RG6346: Phase 1 proof-of-concept data from all existing cohorts – August 2020 R&D Day  GalXC: Present data for extending GalXC technology to additional tissues – August 2020 R&D Day  Nedosiran: Present updated multidose data from PHYOX3 open-label clinical trial – August 2020 R&D Day  Collaborative Program: IND or CTA filing for LY3561774 – late 2020  DCR-A1AT or ALN-AAT02: First patient dosing in Phase 1/2 trial – timing TBD  Nedosiran: PHYOX2 last patient out – timing TBD * Based on changes at trial sites related to COVID-19, on March 26, 2020, Dicerna withdrew its previous expectation for enrollment completion timing. Dicerna will provide a revised timing estimate for PHYOX2 enrollment completion at a later date, and evaluate its potential effect on timing of subsequent activities, such as the nedosiran NDA submission. Dicerna is continuing to evaluate the impact to future studies of nedosiran and future activities in its other clinical trials and development programs and plans to provide an update at a future date. 28 ©2020 DICERNA

29 ©2020 DICERNA