-DCR-MYC is the First Dicer Substrate RNA Interference Candidate to Advance into Clinical Testing-
"The MYC oncogene has been a therapeutic target of great interest for
many years because of its expression in a variety of tumor types and the
demonstration that increased MYC expression is related to the
progression of these cancers," commented
"In preclinical studies, DCR-MYC demonstrated impressive knockdown of
the MYC oncogene," stated
About the Phase 1 Study of DCR-MYC
The multi-center, dose-escalating Phase 1 study will assess the safety and tolerability of DCR-MYC in patients with solid tumors, multiple myeloma, or lymphoma who are refractory or unresponsive to standard therapies. DCR-MYC will be administered by one hour intravenous (IV) infusion, once weekly for three weeks followed by a rest week. The goals of this study are to identify the maximum tolerated dose and study the pharmacokinetic profile, potential pharmacodynamic effects, and antitumor activity of DCR-MYC.
DCR-MYC (DCR-M1711) is Dicerna's novel Dicer Substrate siRNA, a synthetic double-stranded RNA in a stable lipid particle designed to serve as a potent and specific inhibitor of the MYC oncogene. MYC is a key target in oncology because it has been demonstrated to cause or promote cancer when abnormally expressed or activated. Abundant genetic data implicates the MYC oncogene in promoting tumors and inhibition of MYC has exhibited strong anti-tumor effects in numerous animal models of human cancers. Dicerna is investigating DCR-MYC in a variety of tumor types with the initial focus on hepatocellular carcinoma, which is the third leading cause of cancer death worldwide.
Dicerna is a biopharmaceutical company focused on the discovery and development of innovative treatments for rare inherited diseases involving the liver and for cancers that are genetically defined. Dicerna is using its proprietary RNA interference (RNAi) technology platform to build a broad pipeline in these therapeutic areas and intends to discover, develop and commercialize novel therapeutics either on its own or in collaboration with pharmaceutical partners.
Cautionary Note on Forward-Looking Statements
This press release includes forward-looking statements. Such
forward-looking statements are subject to risks and uncertainties that
could cause actual results to differ materially from those expressed or
implied in such statements. Applicable risks and uncertainties include
those identified under the heading "Risk Factors" included in the
prospectus related to the initial public offering, and in other filings
that Dicerna may make with the
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