Document



UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
__________________________________________________
FORM 8-K
__________________________________________________
CURRENT REPORT
Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934
Date of report (Date of earliest event reported): August 8, 2019
__________________________________________________
DICERNA PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)
__________________________________________________
Delaware
 
001-36281
 
20-5993609
(State or other jurisdiction
of incorporation)
 
(Commission
File Number)
 
(I.R.S. Employer
Identification Number)
87 Cambridgepark Drive
Cambridge, Massachusetts
 
02140
(Address of principal executive offices)
 
(Zip Code)
Registrant’s telephone number, including area code: (617) 621-8097
(Former name or former address, if changed since last report)
__________________________________________________
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (See General Instruction A.2 below):
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4c))

Securities registered pursuant to Section 12(b) of the Act:
Title of each class
Trading Symbol(s)
Name of each exchange on which registered
Common stock, $0.0001 Par Value
DRNA
The Nasdaq Global Select Market





Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging growth company  T
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  T

 





Item 2.02    Results of Operations and Financial Condition.
On August 8, 2019, Dicerna Pharmaceuticals, Inc., a Delaware corporation (the “Company”), issued a press release announcing its financial and operational results for the quarter ended June 30, 2019. A copy of the press release is furnished herewith as Exhibit 99.1.
On August 1, 2019, the Company announced that it would hold a conference call and live audio webcast at 4:30 p.m., Eastern Time, on August 8, 2019, to discuss its financial and operational results and to provide a general business update.
The information in this Form 8-K (including Exhibit 99.1 attached hereto) is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section, nor shall such information be deemed to be incorporated by reference in any registration statement or other document filed under the Securities Act of 1933, as amended, or the Exchange Act, except as otherwise stated in such filing.
Item 9.01
Financial Statements and Exhibits.
(d) Exhibits
Exhibit
No.
 
Description
99.1
 





SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Date: August 8, 2019
DICERNA PHARMACEUTICALS, INC.
 
 
 
 
By:
 
/s/ John B. Green
 
 
 
John B. Green
 
 
 
Chief Financial Officer


Exhibit


Exhibit 99.1
http://api.tenkwizard.com/cgi/image?quest=1&rid=23&ipage=13051309&doc=3

Dicerna™ Reports Second Quarter 2019 Financial Results and Provides Corporate Update

- Strengthened Management with Senior Hires Across Medical Affairs, Commercial, Regulatory, and Patient Advocacy and Patient Services -

- Initiated dosing in PHYOX™3 Roll-over Extension Study for the Treatment of Primary Hyperoxaluria (PH) -

- Received Breakthrough Therapy Designation for DCR-PHXC for Treatment of PH1 -

- Announced Clinical Development Plans for DCR-A1AT for Treatment of Patients with Alpha-1 Antitrypsin Deficiency-Associated Liver Disease -

- Management to Host Conference Call Today at 4:30 p.m. ET -

CAMBRIDGE, Mass. - (BUSINESS WIRE) - August 8, 2019 - Dicerna™ Pharmaceuticals, Inc. (Nasdaq: DRNA) (the “Company” or “Dicerna”), a leading developer of investigational ribonucleic acid interference (RNAi) therapeutics, today reported financial results for the second quarter ended June 30, 2019 and provided a corporate update.

“Dicerna is dynamically growing as we move into pivotal development of our lead program in primary hyperoxaluria with an eye toward commercialization. Simultaneously, we’re increasing clinical development and discovery efforts for our own proprietary programs and those in conjunction with our corporate collaborators while expanding the reach of our GalXC RNAi technology,” said Douglas Fambrough, Ph.D., president and chief executive officer of Dicerna. “I’m particularly pleased with the strength and depth of the new leaders who have joined Dicerna to drive these efforts. Notably, Dr. Bernd Hoppe, a renowned global expert in the treatment of primary hyperoxaluria, has joined us as vice president of global medical affairs, and we’re also joined by Rob Ciappenelli as chief commercial officer, Steven Kates as vice president of regulatory affairs, and Dave Caponera as head of patient advocacy and patient services. With these individuals and the rest of our team, we are confident that we will achieve our milestones and deliver innovative and effective therapies to patients in need.”

Recent Clinical and Regulatory Highlights
Initiated dosing in PHYOX™3, a long-term, multi-dose, open label, roll-over extension initially for our Phase 1 study for the treatment of PH.
Received Breakthrough Therapy Designation for DCR-PHXC for the treatment of primary hyperoxaluria type 1 (PH1).
Initiated PHYOX2, a multi-dose, double-blind, randomized, placebo-controlled pivotal trial of DCR-PHXC, which is being investigated for the treatment of all forms of PH.
Presented additional data from PHYOX1 study in patients with PH1 and PH type 2 showing substantial reduction in urinary oxalate following single-dose administration of DCR-PHXC at the Oxalosis and Hyperoxaluria Foundation International Hyperoxaluria Workshop.
Dosed first patient in the Phase 1 clinical trial of DCR-HBVS for the treatment of patients with chronic hepatitis B virus (HBV) infection.





Submitted a clinical trial application to the Swedish Medical Products Agency for DCR-A1AT for the treatment of patients with alpha-1 antitrypsin deficiency-associated (A1AT) liver disease.

Upcoming Clinical and Regulatory Milestones
Dosing of first patient in the pivotal PHYOX2 trial.
Human proof-of-concept data for DCR-HBVS in the first cohort of patients anticipated to be available in the fourth quarter of 2019.
Initiation of a multi-center Phase 1/2 trial of DCR-A1AT is expected in the third quarter of 2019. The proposed parallel-group, placebo-controlled study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of DCR-A1AT in adult healthy volunteers (HVs) and patients with A1AT deficiency-associated liver disease.

Financial Condition and Operating Results for the Second Quarter of 2019
Cash Position - As of June 30, 2019, Dicerna had $345.3 million in cash, cash equivalents, and held-to-maturity investments compared to $302.6 million as of December 31, 2018. Additionally, the Company had $3.5 million and $0.7 million of restricted cash equivalents as of June 30, 2019 and December 31, 2018, respectively, reflecting collateral securing the Company’s lease obligations.
Revenue - Dicerna recognized $5.7 million of revenue associated with its collaboration agreements with Eli Lilly and Company (Lilly), Alexion Pharmaceuticals, Inc. (together with its affiliates, Alexion), and Boehringer Ingelheim International GmbH (BI) during the second quarter ended June 30, 2019 compared with $1.5 million associated solely with BI in the same period in 2018.
Research and Development (R&D) Expenses - R&D expenses were $22.8 million in the second quarter ended June 30, 2019 compared to $10.3 million for the same period in 2018. The increase was primarily due to increased direct R&D costs, as well as employee-related expenses resulting from an increase in headcount necessary to support our growth.
General and Administrative (G&A) Expenses - G&A expenses were $8.8 million for the second quarter ended June 30, 2019 compared to $4.8 million for the same period in 2018. The increase is predominantly due to employee-related expenses, as a result of increased stock-based compensation expense and headcount necessary to support our growth, as well as an increase in general and business development consulting expenses.
Net Loss - Net loss was $23.8 million, or $0.35 per share, for the second quarter ended June 30, 2019 compared to $35.6 million, or $0.68 per share, for the same period in 2018. The decrease for the three months ended June 30, 2019 was primarily due to the absence of litigation expenses along with increased revenues in the second quarter of 2019, partially offset by increases in R&D and G&A expenses.

Guidance
Dicerna believes that its current cash, cash-equivalents, and held-to-maturity investments will be sufficient to fund the execution of its current clinical and operating plan beyond 2020, which includes advancing DCR-PHXC through late-stage clinical development and regulatory filing, completing the proof-of-concept study of DCR-HBVS in participants with HBV, and advancing the Company’s DCR-A1AT program through the initial clinical study. This estimate assumes no new funding from additional collaboration agreements or from external financing events and no significant unanticipated changes in costs and expenses. Dicerna expects its overall R&D expense to continue to increase for the foreseeable future, primarily as the Company completes clinical manufacturing activities, advances preclinical toxicology studies, continues clinical activities associated with its lead product candidates, and increases activities under the Lilly, Alexion, and BI agreements.






Conference Call
Management will host a conference call at 4:30 p.m. ET today to review Dicerna's second quarter 2019 financial results and provide a general business update. The conference call can be accessed by dialing (855) 453-3834 or +1 (484) 756-4306 (international) and referencing conference ID 6279126 prior to the start of the call. The call will also be webcast via the Internet and will be available under the “Investors & Media” section of the Dicerna website, www.dicerna.com. A replay of the call will be available approximately two hours after the completion of the call and will remain available for seven days. To access the replay, please dial (855) 859-2056 or (404) 537-3406 and refer to conference ID 6279126. The webcast will also be archived on Dicerna’s website.

About Dicerna™ Pharmaceuticals, Inc.
Dicerna™ Pharmaceuticals, Inc. (“we”, “us,” “our,” “the Company,” or “Dicerna”) is a biopharmaceutical company using ribonucleic acid (RNA) interference (RNAi) to develop medicines that silence genes that cause disease. The Company’s proprietary GalXC™ technology is being applied to develop potent, selective, and safe RNAi therapies to treat diseases involving the liver, including rare diseases, chronic liver diseases, cardiovascular diseases, and viral infectious diseases. Dicerna aims to treat disease by addressing the underlying causes of illness with capabilities that extend beyond the liver to address a broad range of diseases, focusing on target genes where connections between gene and disease are well understood and documented. Dicerna intends to discover, develop, and commercialize novel therapeutics either on its own or in collaboration with pharmaceutical partners. Dicerna has strategic collaborations with Eli Lilly and Company (Lilly), Alexion Pharmaceuticals, Inc. (Alexion), and Boehringer Ingelheim International GmbH (BI). For more information, please visit www.dicerna.com.

About GalXC™
GalXC™ is a proprietary technology platform invented by Dicerna to discover and develop RNAi-based therapies designed to silence disease-driving genes in the liver. Compounds produced via GalXC are intended to be broadly applicable across multiple therapeutic areas involving the liver, including rare diseases, chronic liver diseases, cardiovascular diseases, and viral infectious diseases. Using GalXC, Dicerna scientists attach N‑acetylgalactosamine sugars directly to the extended region of the Company’s proprietary RNAi molecules, yielding multiple proprietary conjugate delivery configurations. Many of the conjugates produced via GalXC incorporate a folded motif known as a tetraloop in the extended region. The tetraloop configuration, which is unique to Dicerna’s GalXC compounds, allows flexible and efficient conjugation to the targeting ligands and stabilizes the RNAi duplex, which the Company believes will enable subcutaneous delivery of its RNAi therapies to hepatocytes in the liver, where they are designed to specifically bind to receptors on target cells, potentially leading to internalization and access to the RNAi machinery within the cells. The technology may offer several distinct benefits, as suggested by strong preclinical data. The benefits seen in preclinical studies include: potency that is on par with or better than comparable platforms, highly specific binding to gene targets, long duration of action, and an infrequent subcutaneous dosing regimen.

Cautionary Note on Forward-Looking Statements
This press release includes forward-looking statements. Such forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements. Examples of forward-looking statements include, among others, statements we make regarding: (i) the therapeutic and commercial potential of DCR-PHXC, DCR-HBVS, DCR-A1AT, and the GalXC™ platform; (ii) research and development plans and timelines related to DCR-PHXC, DCR-HBVS, DCR-A1AT, and GalXC; (iii) the potential of Dicerna’s technology and drug candidates in the Company’s research and development pipeline, and (iv) Dicerna’s financial position and cash runway. The process by which an early stage investigational therapy such as DCR-PHXC, DCR-HBVS, DCR-





A1AT, and an early stage platform such as GalXC could potentially lead to an approved product is long and subject to highly significant risks. Applicable risks and uncertainties include those relating to Dicerna’s clinical research and other risks identified under the heading "Risk Factors" included in the Company’s most recent Form 10-Q filing and in other future filings with the Securities and Exchange Commission. These risks and uncertainties include, among others, the cost, timing, and results of preclinical studies and clinical trials and other development activities; the likelihood of Dicerna’s clinical programs being executed on timelines provided and reliance on the Company’s contract research organizations and predictability of timely enrollment of subjects and patients to advance Dicerna’s clinical trials; the potential for future data to alter initial and preliminary results of early stage clinical trials; the future agreement on clinical endpoints for all forms of PH, the unpredictability of the duration and results of the regulatory review of Investigational New Drug Applications (NDAs) and Clinical Trial Applications that are necessary to continue to advance and progress the Company’s clinical programs and the regulatory review of NDAs; market acceptance for approved products and innovative therapeutic treatments; competition; the possible impairment of, inability to obtain, and costs to obtain intellectual property rights; possible safety or efficacy concerns that could emerge as new data are generated in R&D; and general business, financial, and accounting risks and litigation. The forward-looking statements contained in this press release reflect Dicerna's current views with respect to future events, and Dicerna does not undertake and specifically disclaims any obligation to update any forward-looking statements.

Dicerna™, GalXC™, and PHYOX™ are trademarks of Dicerna Pharmaceuticals, Inc.





DICERNA PHARMACEUTICALS, INC.
SELECTED FINANCIAL INFORMATION (UNAUDITED)
Condensed Consolidated Balance Sheets
 
June 30,
2019
 
December 31,
2018
(In thousands, except share data)
 
 
Cash and cash equivalents
 
$
100,321

 
$
54,239

Held-to-maturity investments
 
244,969

 
248,387

Contract receivables
 

 
100,000

Prepaid expenses and other current assets
 
4,958

 
2,888

Property and equipment, net
 
4,915

 
2,718

Right-of-use asset
 
2,627

 

Restricted cash equivalents
 
3,544

 
744

Other noncurrent assets
 
62

 
65

Total Assets
 
$
361,396

 
$
409,041

Accounts payable
 
$
5,636

 
$
5,013

Accrued expenses and other current liabilities
 
10,515

 
9,649

Lease liability, current
 
1,648

 

Litigation settlement payable
 

 
10,500

Deferred revenue, current
 
78,073

 
68,893

Lease liability, noncurrent
 
1,035

 

Deferred revenue, noncurrent
 
104,324

 
114,293

Total stockholders’ equity
 
160,165

 
200,693

Total Liabilities and Stockholders' Equity
 
$
361,396

 
$
409,041

 
 
 
 
 
Common stock outstanding
 
68,360,051

 
68,210,742






Condensed Consolidated Statements of Operations
 
 Three Months Ended
June 30, 2019
 
 Three Months Ended
June 30, 2018
(In thousands, except per share data)
 
 
Revenue from collaborative arrangements
 
$
5,682

 
$
1,545

Operating expenses:
 
 
 
 
Research and development
 
22,832

 
10,339

General and administrative
 
8,831

 
4,760

Litigation expense
 

 
22,244

Total operating expenses
 
31,663

 
37,343

Loss from operations
 
(25,981
)
 
(35,798
)
Other income (expense):
 
 
 
 
Interest income
 
2,136

 
330

Interest expense
 

 
(176
)
Total other income, net
 
2,136

 
154

Net loss
 
$
(23,845
)
 
$
(35,644
)
Net loss per share – basic and diluted
 
$
(0.35
)
 
$
(0.68
)
Weighted average common shares outstanding – basic and diluted
 
68,323,850

 
52,555,751

Condensed Consolidated Statements of Operations
 
Six Months Ended
June 30, 2019
 
Six Months Ended
June 30, 2018
(In thousands, except per share data)
 
 
Revenue from collaborative arrangements
 
$
8,789

 
$
3,090

Operating expenses:
 
 
 
 
Research and development
 
44,435

 
20,232

General and administrative
 
18,507

 
9,095

Litigation expense
 

 
25,428

Total operating expenses
 
62,942

 
54,755

Loss from operations
 
(54,153
)
 
(51,665
)
Other income (expense):
 
 
 
 
Interest income
 
4,154

 
619

Interest expense
 

 
(176
)
Total other income, net
 
4,154

 
443

Net loss
 
$
(49,999
)
 
$
(51,222
)
Net loss per share – basic and diluted
 
$
(0.73
)
 
$
(0.98
)
Weighted average common shares outstanding – basic and diluted
 
68,292,212

 
52,141,849


Contacts

Investors:
Stern Investor Relations, Inc.
Lauren Stival, 212-362-1200
lauren.stival@sternir.com

Media:
SmithSolve
Alex Van Rees, 973-442-1555 ext. 111
alex.vanrees@smithsolve.com