Investors & Media
Douglas M. Fambrough, III, Ph.D., co-founded Dicerna in 2007 and has served as the Company’s chief executive officer since 2010. Prior to joining Dicerna as CEO, Dr. Fambrough specialized in financing innovative life science technology companies as a general partner with Oxford Bioscience Partners, a Boston-based venture capital firm.
In 2003, Dr. Fambrough and two other investors founded Sirna Therapeutics, a first-generation RNA interference (RNAi) pioneer; he served on Sirna’s Board of Directors until the company was acquired by Merck for $1.1 billion in 2006. Other investments include Solexa, developer of the dominant ultra-high-throughput DNA sequencing platform, acquired by Illumina for $600 million; and Cambrios Technologies, which invented and now markets biologically inspired electronic materials for touch screens and flat panel displays. Before joining Oxford, Dr. Fambrough was a genomic scientist at the Whitehead/MIT Center for Genome Research (now known as the Broad Institute).
Dr. Fambrough graduated from Cornell University and obtained his Ph.D. in genetics at the University of California, Berkeley.
Bob Brown, Ph.D., joined Dicerna as senior vice president, research in 2008. Prior to joining Dicerna, he had a long career at Genta, where he was vice president, research and technology and had more than 75 issued patents and patent applications.
While at Genta, Dr. Brown became one of the only R&D executives in the biotechnology industry to follow a systemically administered oligonucleotide therapeutic (Genasense™) from the research bench through Phase 1, 2 and 3 clinical trials and NDA review. He worked directly with clinicians and study investigators on trial design, execution and interpretation of results. In addition to his roles at Genta, Dr. Brown was co-founder and vice president of research and development at Oasis Biosciences.
Dr. Brown holds a Ph.D. in molecular biology from the University of California, Berkeley, and B.S. degrees in chemistry and biology from the University of Washington.
Rob Ciappenelli joined Dicerna as chief commercial officer in 2019, with more than 28 years of experience working across various pharmaceutical, biotech, and healthcare consulting industries. Most recently, he was global head of commercial at Momenta Pharmaceuticals.
In that capacity, Mr. Ciappenelli managed a portfolio of 13 programs ranging from early development to partnered in-market products.
Prior to Momenta, he held several leadership positions at Shire Pharmaceuticals (now part of Takeda), across commercial operations and business planning including global franchise operations lead for Shire’s Fabry (Replagal®) and Gaucher (Vpriv®) programs. Mr. Ciappenelli’s pharmaceutical commercialization experience also includes various leadership positions at Sunovion Pharmaceuticals, where he served as vice president of commercial operations, executive director of commercial services and sales training, and executive director of central nervous system marketing. His expertise spans rare disease, neurological disorders, and diseases of the respiratory and gastrointestinal systems.
Mr. Ciappenelli earned a Bachelor of Business Administration (B.B.A.) in Finance from the University of Massachusetts at Amherst and a Master of Business Administration (M.B.A.) from the Harvard Graduate School of Business Administration.
Jack Green joined Dicerna as chief financial officer in April 2016. Prior to Dicerna, he was chief financial officer of Verastem, Inc. Previously, Mr. Green served for over 15 years as chief financial officer of GTC Biotherapeutics, Inc. (formerly Genzyme Transgenics Corporation), which was spun out from Genzyme Corporation as a stand-alone public company.
Mr. Green is a Certified Public Accountant (CPA) with over 30 years of financial management experience, including 20 within the biotechnology industry. He received a master’s degree in business administration from Boston University Graduate School of Management and a bachelor’s degree from the College of the Holy Cross, where he majored in economics and accounting.
Jennifer Lockridge, Ph.D., is vice president of program development at Dicerna Pharmaceuticals and has 20 years of experience in the development of oligonucleotide therapeutics. Prior to joining Dicerna, Dr. Lockridge spent nine years consulting with multiple biotech and large pharmaceutical companies to provide direction and support for early development-stage oligonucleotide programs as well as pharmacology and pharmacokinetics expertise.
From 1996 to 2007, Dr. Lockridge was employed at Sirna Therapeutics, Inc. (formerly Ribozyme Pharmaceuticals, Inc.). As director of project management at Sirna, she managed and was involved with all aspects of siRNA and ribozyme development programs. Dr. Lockridge received her Ph.D. in pharmacology from the Oregon Health Sciences University in Portland, Ore., and pursued postdoctoral training at the FDA’s National Center for Toxicological Research in Jefferson, Ark.
David Miller, Ph.D., is senior vice president, corporate operations/ alliance management at Dicerna Pharmaceuticals, which he joined in 2008. Over the course of his career, he has successfully combined leadership roles in both business and research capacities. He has been a member of five early-stage biotech companies, each of which has successfully transitioned to a public company.
At Dicerna, Dr. Miller has also served as vice president of research operations and of business development. Previously, he was senior director, business development at Synta Pharmaceuticals, where he had partnering responsibility for the company’s oncology portfolio and played a lead role in a pharma partnership, valued at over $1 billion. Prior to Synta, he was director, business development at Altus Biologics, where his responsibilities included developing the drug delivery business and the partnering of several biological products. Dr. Miller was a founder and the head of research for EcoScience Corporation, an agricultural biotechnology company. He began his career at Genetics Institute. Dr. Miller is the inventor on six issued United States patents. He is a board member of EcoPesticides International, a New Mexico company, and serves on several public boards in his hometown of Winchester, Mass.
Dr. Miller holds a Ph.D. in molecular biology and biochemistry from Harvard University and a B.S. in biochemistry and biophysics from the University of California, Davis.
Regina DeTore Paglia is the senior vice president of human resources and has more than 25 years of experience in human resources management at numerous biopharmaceutical, biochemical, and managed care companies from early-stage start-up to full commercial operations.
Most recently, she was senior vice president of human resources at Paratek Pharmaceuticals, reporting directly to the chief executive officer and chairman as a member of the executive leadership team. Prior to that, she was vice president (2010-12) and senior vice president (2012-15) of human resources at Myriant Corporation, a biochemical company that is a subsidiary of PTTGC Global Chemical Company. From 2008 to 2010, Ms. Paglia was vice president of human resources at Mascoma Corporation, a biofuels company. She has also held several executive positions in human resources at Sepracor Pharmaceuticals and Tufts Health Plans.
Ms. Paglia is the 2018 recipient of the Bob Gatti HR Leadership Excellence Award of Distinction from the Human Resources Leadership Forum. She holds a bachelor’s degree in business management and marketing from Sawyer Business School at Suffolk University in Beacon Hill, Mass., and a master’s degree in human resources management from Framingham (Mass.) State College.
Ralf Rosskamp, M.D., joined Dicerna as chief medical officer in June 2017, and is responsible for leading the Company’s clinical development, medical affairs and regulatory functions. Dr. Rosskamp has more than 20 years of research and development (R&D) experience spanning the entire drug development cycle, from pre-clinical through product commercialization.
Prior to joining Dicerna, Dr. Rosskamp was chief medical officer at Summit Therapeutics. In this role, he directed and oversaw all clinical development and medical activities for Summit’s investigational therapies for the rare genetic disease Duchenne muscular dystrophy and the infectious disease caused by Clostridium difficile bacteria. Prior to Summit, Dr. Rosskamp held executive-level positions in clinical research and drug development at NPS Pharmaceuticals (acquired by Shire), Ikaria, Kos Pharmaceuticals (acquired by Abbott Laboratories), Aventis Pharmaceuticals (formerly Hoechst Marrion Roussel), and Hoechst AG.
Dr. Rosskamp has been responsible for numerous investigational new drug applications, the design and execution of clinical development programs, and new drug applications across multiple therapeutic areas including diabetes, cardiovascular, respiratory and orphan drugs. He was involved in the development of several approved products including Amaryl®, Lantus®, Apidra®, Simcor® and Natpara®.
Dr. Rosskamp is a member of the Board of Directors of Bioblast Pharma in Tel Aviv, Israel. He has authored more than 20 peer-reviewed publications and published more than 50 scientific abstracts. Dr. Rosskamp is a pediatric endocrinologist with more than 15 years of experience in clinical medicine. He received his M.D. from the University of Bonn, Germany.
James B. Weissman joined Dicerna as chief business officer in January 2012. He has more than 30 years’ experience in the life sciences industry, with extensive international management experience in biotech and pharmaceutical general management, product development, licensing, business development, marketing and M&A activities.
Prior to Dicerna, Mr. Weissman was vice president of business development at MannKind Corporation, responsible for leading the company’s activities related to licensing, new products and strategic planning. Prior to MannKind, Mr. Weissman held leadership positions in both business development and marketing at Pfizer Pharmaceuticals, Inc. in Tokyo, most recently as senior director of marketing. In that position, he was responsible for the sales, profit and strategic targets for the company’s specialty products, including central nervous system (CNS), endocrinology, ophthalmology and oncology therapeutics and diversified portfolios. He is a board member of Receptor Lice Sciences, a private company developing FDA-regulated oral and inhaled cannabinoid medicines.
Mr. Weissman holds a Bachelor of Science degree from Bates College.